With both teams already through, Real Madrid must beat Borussia Dortmund on matchday six if they are to progress to the last 16 of the Uefa Champions League as Group F winners.
Dortmund, who beat Legia Warszawa 8-4 last time out, hold a two-point advantage over Madrid going into their final fixture of the group stage and need only a draw to cement first place.
The clubs drew 2-2 in Germany on matchday two, André Schürrle hitting an 87th-minute equaliser to snatch a point for Dortmund.
Madrid are unbeaten in five previous encounters with Dortmund in Spain.
Prior to this season, the clubs last met in the 2013/14 Uefa Champions League quarterfinals, Madrid prevailing 3-2 on aggregate en route to lifting the trophy.
Gareth Bale, Isco and Cristiano Ronaldo earned Carlo Ancelotti’s Madrid a 3-0 first-leg lead before Dortmund, managed by Jürgen Klopp, fell just short of a fine comeback despite a 2-0 victory in Germany through two Marco Reus strikes.
Madrid: Casillas, Carvajal, Pepe, Ramos, Fábio Coentrão, Alonso, Modric, Isco (Illarramendi 72), Ronaldo (Casemiro 80), Bale, Benzema (Morata 75).
Dortmund: Weidenfeller, Piszczek (Schieber 67), Papastathopoulos, Hummels, Durm, Kehl (Jojic 74), Nuri Sahin, Reus, Mkhitaryan (Hofmann 64), Grosskreutz, Aubameyang.
The teams met in the group stage of the 2012/13 competition, when Dortmund finished above Madrid with the help of a 2-1 home win – Robert Lewandowski and Marcel Schmelzer scoring either side of Ronaldo – and a 2-2 draw in Madrid where Pepe and Reus featured on the scoresheet.
The clubs were reunited in the semifinals that season and Dortmund won the first leg 4-1 at home, Lewandowski getting all four goals to send his side through despite a 2-0 reverse in Madrid where Karim Benzema and Sergio Ramos scored.
Roman Weidenfeller is the solitary survivor of the sides’ meetings in the 2002/03 second group stage, when Madrid won 2-1 at the Bernabéu and then drew 1-1 in Dortmund. Zinédine Zidane played in both matches too.
Dortmund sporting director Michael Zorc and youth-team coordinator Lars Ricken played in Dortmund’s 1997/98 Uefa Champions League semifinal loss to Madrid (0-2 a, 0-0 h).